Bufferin Lunai
バファリンルナi
Combination analgesic and antipyretic (ibuprofen + acetaminophen)
Tablets
Relief of menstrual pain, headache, back pain, shoulder stiffness pain, muscle pain, joint pain, bruising pain, fracture pain, sprain pain, toothache, post-extraction pain, neuralgia, earache, traumatic pain, and sore throat; and reduction of fever and chills
Active Ingredients (per 2 tablets)
• Ibuprofen 130mg • Acetaminophen 130mg • Anhydrous caffeine 80mg • Dehydrated aluminum hydroxide gel 70mg
Inactive Ingredients
Hydroxypropylcellulose, D-mannitol, lactic acid, magnesium stearate, polyvinyl alcohol (partially saponified), talc, titanium oxide, glycerol fatty acid ester, sodium lauryl sulfate
Instructions for Use
- ✓Take with lukewarm or cold water. Avoid taking on an empty stomach. Allow at least 4 hours between doses.
| Age | Dose per use | Times per day |
|---|---|---|
| Adults (15 years and older) | 2 tablets | Up to 3 times daily |
| Under 15 years | Do not use | — |
- ✕Do not take if you have had an allergic reaction to this product or any of its ingredients.
- ✕Do not take if you have experienced an asthma attack triggered by this product, other analgesics or antipyretics, or cold medicines.
- ✕Do not take if you are under 15 years of age.
- ✕Do not take if you are pregnant and within 12 weeks of your due date.
- ✕Do not use with other analgesics/antipyretics, cold medicines, or sedatives.
- ✕Do not drink alcohol before or after taking this medication.
- ✕Do not take for an extended period.
- ✓If any of the following occur after taking, stop immediately and consult a physician, dentist, pharmacist, or registered salesperson: skin rash, redness, itchiness, or bruising; nausea, vomiting, loss of appetite, stomach discomfort, stomach pain, mouth sores, heartburn, bloating, gastrointestinal bleeding, abdominal pain, diarrhea, or bloody stool; dizziness; palpitations; shortness of breath; or blurred vision, tinnitus, swelling, nosebleed, bleeding gums, back pain, excessive temperature decrease, or lethargy.
- ✓If constipation persists or worsens after taking, stop use and consult a physician, pharmacist, or registered salesperson.
- ✓Seek immediate medical attention if you experience itching, hives, hoarseness, difficulty breathing, palpitations, or clouded consciousness (possible anaphylactic shock); high fever, eye redness, eye discharge, lip sores, or widespread skin rash or redness (possible Stevens-Johnson syndrome, toxic epidermal necrolysis, or acute generalized exanthematous pustulosis); widespread skin redness, fever, and swollen lymph nodes (possible drug-induced hypersensitivity syndrome); fever, jaundice, or dark urine (possible liver damage); fever, rash, decreased urination, swelling, or joint pain (possible kidney disorder); severe headache with neck stiffness and fever (possible aseptic meningitis); chest tightness, difficulty breathing, or cold sweats (possible myocardial infarction); sudden difficulty moving one side of the body or speaking (possible cerebrovascular disorder); shortness of breath on exertion or persistent dry cough and fever (possible interstitial pneumonia); wheezing or difficulty breathing (possible asthma); bruising, nosebleeds, bleeding gums, fever, pale skin, fatigue, or blood in urine (possible aplastic anemia); or sudden high fever, chills, or sore throat (possible agranulocytosis).
- ⚠Consult a physician, dentist, pharmacist, or registered salesperson before use if you: are currently receiving medical or dental treatment; are pregnant or may be pregnant; are nursing; are elderly; have had an allergic reaction to any drug; have been diagnosed with heart disease, kidney disease, liver disease, systemic lupus erythematosus, or mixed connective tissue disease; or have a history of gastric or duodenal ulcers, ulcerative colitis, or Crohn's disease.
- ✓Seek immediate medical attention if any of the following serious symptoms appear:
- • Shock (anaphylaxis): Itching of skin, hives, hoarseness, sneezing, itchy throat, difficulty breathing, palpitations, or clouding of consciousness immediately after use.
- • Stevens-Johnson syndrome / toxic epidermal necrolysis: High fever, redness of eyes, eye discharge, sores on lips, sore throat, or widespread rash or redness on skin that persists or rapidly worsens.
- • Liver disorder: Fever, itching, rash, jaundice (yellowing of the skin or whites of the eyes), dark urine, general fatigue, or loss of appetite.
- • Kidney disorder: Fever, rash, decreased urine output, swelling throughout the body, general fatigue, joint pain, or diarrhea.
- • Aseptic meningitis: Severe headache with stiff neck, fever, nausea, or vomiting. (More common in people with systemic lupus erythematosus or mixed connective tissue disease.)
- • Myocardial infarction: Squeezing chest pain, difficulty breathing, or cold sweat.
- • Cerebrovascular disorder: Sudden onset of decreased or loss of consciousness, difficulty moving one side of the body, headache, vomiting, dizziness, slurred speech, or difficulty finding words.
- • Asthma: Wheezing or whistling breath sounds, or difficulty breathing.
- • Aplastic anemia: Bruising, nosebleed, bleeding gums, fever, pale skin or mucous membranes, fatigue, palpitations, shortness of breath, feeling faint, or blood in urine.
- • Agranulocytosis: Sudden high fever, chills, or sore throat.
- ✓Strictly follow the prescribed dosage.
- ✓When removing the tablet from the PTP sheet, press the convex side firmly to break the foil on the back. Do not swallow the PTP sheet.
- ✓If symptoms do not improve after 5 to 6 doses, stop use and consult a physician, dentist, pharmacist, or registered salesperson.
Sources & Documents
- Japanese product page
- English PDF
- Japanese PDF
- Last verified: May 23, 2026
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For informational purposes only. Always consult a doctor or pharmacist before taking any medication.